Effects of ASKP1240 Combined With Tacrolimus or Mycophenolate Mofetil on Renal Allograft Survival in Cynomolgus Monkeys

BACKGROUND: Blocking the CD40-CD154 signal pathway has previously shown promise as a strategy to prevent allograft rejection. In this study, the efficacy of a novel fully human anti-CD40 monoclonal antibody—ASKP1240, administered as a monotherapy or combination therapy (subtherapeutic dose of tacrol...

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Detalhes bibliográficos
Main Authors: Song, Lijun, Ma, Anlun, Dun, Hao, Hu, Yanxin, Zeng, Lin, Bai, Jieying, Zhang, Guangzhou, Kinugasa, Fumitaka, Sudo, Yuji, Miyao, Yasuhiro, Okimura, Kazumichi, Miura, Toru, Daloze, Pierre, Chen, Huifang
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
Assuntos:
Basic and Experimental Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175122/
https://ncbi.nlm.nih.gov/pubmed/24992357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000236
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