Comparative effectiveness of next generation genomic sequencing for disease diagnosis: Design of a randomized controlled trial in patients with colorectal cancer/polyposis syndromes()

Whole exome and whole genome sequencing are applications of next generation sequencing transforming clinical care, but there is little evidence whether these tests improve patient outcomes or if they are cost effective compared to current standard of care. These gaps in knowledge can be addressed by...

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Main Authors: Gallego, Carlos J., Bennette, Caroline S., Heagerty, Patrick, Comstock, Bryan, Horike-Pyne, Martha, Hisama, Fuki, Amendola, Laura M., Bennett, Robin L., Dorschner, Michael O., Tarczy-Hornoch, Peter, Grady, William M., Fullerton, S. Malia, Trinidad, Susan B., Regier, Dean A., Nickerson, Deborah A., Burke, Wylie, Patrick, Donald L., Jarvik, Gail P., Veenstra, David L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175052/
https://ncbi.nlm.nih.gov/pubmed/24997220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2014.06.016
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