Φορτώνει......
Structure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction
[Image: see text] Calcineurin inhibitors such as cyclosporine A and FK506 are effective immunosuppressants but produce severe side effects. Rational modification of a previously reported peptide inhibitor, GPHPVIVITGPHEE (K(D) ∼ 500 nM), by replacing the two valine residues with tert-leucine and the...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2014
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4174996/ https://ncbi.nlm.nih.gov/pubmed/25162754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500743t |
| Ετικέτες: |
Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!
|