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Downregulation of MicroRNA-21 is Involved in the Propofol-Induced Neurotoxicity Observed in Human Stem Cell-Derived Neurons

BACKGROUND: Recent studies in various animal models have suggested that anesthetics such as propofol, when administered early in life, can lead to neurotoxicity. These studies have raised significant safety concerns regarding the use of anesthetics in the pediatric population and highlight the need...

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Autori principali: Twaroski, Danielle M., Yan, Yasheng, Olson, Jessica M., Bosnjak, Zeljko J., Bai, Xiaowen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174986/
https://ncbi.nlm.nih.gov/pubmed/24950164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000345
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