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Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease free survival

PURPOSE: Obesity-related hormones and cytokines alter PI3K-AKT-mTOR pathway activation in breast tumors contributing to poorer disease-free survival (DFS) and decreased responsiveness to tamoxifen and trastuzumab. We hypothesized that single nucleotide polymorphisms (SNPs) in candidate genes in the...

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Autores principales: Pande, Mala, Bondy, Melissa L., Do, Kim-Anh, Sahin, Aysegul A., Ying, Jun, Mills, Gordon B., Thompson, Patricia A., Brewster, Abenaa M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174407/
https://ncbi.nlm.nih.gov/pubmed/25108739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-014-3081-9
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