Hsp70-Bag3 interactions regulate cancer-related signaling networks

Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling. Using several complementary approaches, we established that the Hsp70-Bag...

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Autores principales: Colvin, T.A., Gabai, V.L., Gong, J., Calderwood, S.K., Li, H., Gummuluru, S., Matchuk, O.N, Smirnova, S.G, Orlova, N.V, Zamulaeva, I.A, Garcia-Marcos, M., Li, X., Young, Z.T., Rauch, J.N., Gestwicki, J.E., Takayama, S., Sherman, M.Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174322/
https://ncbi.nlm.nih.gov/pubmed/24994713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0747
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