Effect of Procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3

In hepatocytes, aging-associated decline in GSH has been linked to activation of neutral SMase (nSMase), accumulation of bioactive ceramide, and inflammation. In this study, we seek to test whether dietary supplementation with the cysteine precursor, L-2-oxothiazolidine-4-carboxylic acid (OTC), woul...

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Autori principali: Deevska, Gergana, Sunkara, Manjula, Karakashian, Claudia, Peppers, Benjamin, Morris, Andrew J., Nikolova-Karakashian, Mariana N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173997/
https://ncbi.nlm.nih.gov/pubmed/25047167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M048223
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