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RNAi or overexpression: Alternative therapies for Spinocerebellar Ataxia Type 1
Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant late onset neurodegenerative disease caused by an expanded polyglutamine tract in ataxin-1. Here, we compared the protective effects of overexpressing ataxin-1-like using recombinant AAVs, or reducing expression of mutant ataxin-1 using v...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4173078/ https://ncbi.nlm.nih.gov/pubmed/23583610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.04.003 |
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