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Improving the accuracy of the structure prediction of the third hypervariable loop of the heavy chains of antibodies

Motivation: Antibodies are able to recognize a wide range of antigens through their complementary determining regions formed by six hypervariable loops. Predicting the 3D structure of these loops is essential for the analysis and reengineering of novel antibodies with enhanced affinity and specifici...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Messih, Mario Abdel, Lepore, Rosalba, Marcatili, Paolo, Tramontano, Anna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173008/
https://ncbi.nlm.nih.gov/pubmed/24930144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu194
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