Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers

BACKGROUND: DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase I belongs to the family of poly(ADP-ribose)-binding proteins and is the target of camptothecin derived anticancer drugs. Poly(ADP-ribosyl)a...

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Autors principals: Tesauro, Cinzia, Graziani, Grazia, Arnò, Barbara, Zuccaro, Laura, Muzi, Alessia, D’Annessa, Ilda, Santori, Elettra, Tentori, Lucio, Leonetti, Carlo, Fiorani, Paola, Desideri, Alessandro
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172901/
https://ncbi.nlm.nih.gov/pubmed/25227992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-014-0071-z
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