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Dual Role of Endothelial Nitric Oxide Synthase in Oxidized LDL-Induced, p66(Shc)-Mediated Oxidative Stress in Cultured Human Endothelial Cells
BACKGROUND: The aging gene p66(Shc), is an important mediator of oxidative stress-induced vascular dysfunction and disease. In cultured human aortic endothelial cells (HAEC), p66(Shc) deletion increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability via pro...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172699/ https://ncbi.nlm.nih.gov/pubmed/25247687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107787 |
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