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APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the normal function of APP in synaptic transmission, sy...

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Detalhes bibliográficos
Main Authors: Del Prete, Dolores, Lombino, Franco, Liu, Xinran, D'Adamio, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172690/
https://ncbi.nlm.nih.gov/pubmed/25247712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108576
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