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APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions
Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the normal function of APP in synaptic transmission, sy...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
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Public Library of Science
2014
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172690/ https://ncbi.nlm.nih.gov/pubmed/25247712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108576 |
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