The transcriptional regulator Aire co-opts the repressive ATF7ip-MBD1 complex for induction of immune tolerance

The maintenance of immune tolerance requires the deletion of self-reactive T cells in the thymus. The expression of tissue-specific antigen genes (TSAs) by thymic epithelial cells is critical for this process and depends on the activity of the Autoimmune Regulator (Aire) protein, however, the molecu...

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Main Authors: Waterfield, Michael, Khan, Imran S., Cortez, Jessica T., Fan, Una, Metzger, Todd, Greer, Alexandra, Fasano, Kayla, Martinez-Llordella, Marc, Pollack, Joshua L., Erle, David J., Su, Maureen, Anderson, Mark S.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172453/
https://ncbi.nlm.nih.gov/pubmed/24464130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2820
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