A Neuropharmacokinetic Assessment of Bafetinib, a Second Generation Dual BCR-Abl/Lyn Tyrosine Kinase Inhibitor, in Patients with Recurrent High-Grade Gliomas

PURPOSE: The primary objective of this study was to use intracerebral microdialysis (ICMD) to determine the neuropharmacokinetics of bafetinib, a dual BCR-Abl/Lyn tyrosine kinase inhibitor that may have activity against gliomas. METHODS: A microdialysis catheter was placed into either peritumoral or...

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Detalhes bibliográficos
Main Authors: Portnow, Jana, Badie, Behnam, Markel, Susan, Liu, An, D'Apuzzo, Massimo, Frankel, Paul, Jandial, Rahul, Synold, Timothy W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172445/
https://ncbi.nlm.nih.gov/pubmed/23380277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2013.01.001
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