SHIP1 Regulates MSC Numbers and Their Osteolineage Commitment by Limiting Induction of the PI3K/Akt/β-Catenin/Id2 Axis

Here, we show that Src homology 2-domain-containing inositol 5′-phosphatase 1 (SHIP1) is required for the efficient development of osteoblasts from mesenchymal stem cells (MSCs) such that bone growth and density are reduced in mice that lack SHIP1 expression in MSCs. We find that SHIP1 promotes the...

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Detalhes bibliográficos
Main Authors: Iyer, Sonia, Viernes, Dennis R., Chisholm, John D., Margulies, Bryan S., Kerr, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172390/
https://ncbi.nlm.nih.gov/pubmed/24857423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0122
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