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The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase and tensin homolog deleted on chromosome 10 dephosphorylates PIP3 to PIP2, and thus, negatively regulates the pathway. AKT (v-...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172058/ https://ncbi.nlm.nih.gov/pubmed/25295225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00252 |
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