The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

Altered DAB2IP gene expression often detected in prostate cancer (PCa) is due to epigenetic silencing. In this study, we unveil a new mechanism leading to the loss of DAB2IP protein; an oncogenic S-phase kinase-associated protein-2 (Skp2) as E3 ubiquitin ligase plays a key regulator in DAB2IP degrad...

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Bibliografiske detaljer
Main Authors: Tsai, Yuh-Shyan, Lai, Chen-Li, Lai, Chih-Ho, Chang, Kai-Hsiung, Wu, Kaijie, Tseng, Shu-Fen, Fazli, Ladan, Gleave, Martin, Xiao, Guanghua, Gandee, Leah, Sharifi, Nima, Moro, Loredana, Tzai, Tzong-Shin, Hsieh, Jer-Tsong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171641/
https://ncbi.nlm.nih.gov/pubmed/25115390
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