The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

Altered DAB2IP gene expression often detected in prostate cancer (PCa) is due to epigenetic silencing. In this study, we unveil a new mechanism leading to the loss of DAB2IP protein; an oncogenic S-phase kinase-associated protein-2 (Skp2) as E3 ubiquitin ligase plays a key regulator in DAB2IP degrad...

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Detalhes bibliográficos
Main Authors: Tsai, Yuh-Shyan, Lai, Chen-Li, Lai, Chih-Ho, Chang, Kai-Hsiung, Wu, Kaijie, Tseng, Shu-Fen, Fazli, Ladan, Gleave, Martin, Xiao, Guanghua, Gandee, Leah, Sharifi, Nima, Moro, Loredana, Tzai, Tzong-Shin, Hsieh, Jer-Tsong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171641/
https://ncbi.nlm.nih.gov/pubmed/25115390
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