Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy

Cylindromatosis (CYLD) is a tumor suppressor that regulates signaling pathways by acting as a deubiquitinating enzyme. CYLDdown-regulation occurred in several malignancies, with tumor-promoting effects. Although we found loss of CYLD expression in hypoxic regions of human glioblastoma multiforme (GB...

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Detalhes bibliográficos
Main Authors: Guo, Jianying, Shinriki, Satoru, Su, Yu, Nakamura, Takuya, Hayashi, Mitsuhiro, Tsuda, Yukimoto, Murakami, Yoshitaka, Tasaki, Masayoshi, Hide, Takuichiro, Takezaki, Tatsuya, Kuratsu, Jun-ichi, Yamashita, Satoshi, Ueda, Mitsuharu, Li, Jian-Dong, Ando, Yukio, Jono, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171635/
https://ncbi.nlm.nih.gov/pubmed/25071012
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