MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R

We found that restoration of miR-100 expression resulted in accumulation of LC3B-II and decrease of p62 in hepatocellular carcinoma (HCC) cells, whereas antagonism of miR-100 reduced the level of LC3B-II. Moreover, a significant correlation between miR-100 downregulation and p62 upregulation was obs...

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Hlavní autoři: Ge, Yi-Yuan, Shi, Qing, Zheng, Zhi-Yuan, Gong, Jiao, Zeng, Chunxian, Yang, Jine, Zhuang, Shi-Mei
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171624/
https://ncbi.nlm.nih.gov/pubmed/25026290
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