Triplet repeat expansion in myotonic dystrophy alters the adjacent chromatin structure.
Myotonic dystrophy is caused by an expansion of a CTG triplet repeat sequence in the 3' noncoding region of a protein kinase gene, yet the mechanism by which the triplet repeat expansion causes disease remains unknown. This report demonstrates that a DNase I hypersensitive site is positioned 3' of t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777532/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5465 |
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