Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies

HER2, a ligand-free tyrosine kinase receptor of the HER family, is frequently overexpressed in breast cancer. The anti-HER2 antibody trastuzumab has shown significant clinical benefits in metastatic breast cancer; however, resistance to trastuzumab is common. The development of monoclonal antibodies...

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Hlavní autoři: Fu, Wenyan, Wang, Yuxiao, Zhang, Yunshan, Xiong, Lijuan, Takeda, Hiroaki, Ding, Li, Xu, Qunfang, He, Lidong, Tan, Wenlong, Bethune, Augus N., Zhou, Lijun
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171031/
https://ncbi.nlm.nih.gov/pubmed/24838231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28786
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