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Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies
HER2, a ligand-free tyrosine kinase receptor of the HER family, is frequently overexpressed in breast cancer. The anti-HER2 antibody trastuzumab has shown significant clinical benefits in metastatic breast cancer; however, resistance to trastuzumab is common. The development of monoclonal antibodies...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4171031/ https://ncbi.nlm.nih.gov/pubmed/24838231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28786 |
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