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A new tool for monoclonal antibody analysis: Application of IdeS proteolysis in IgG domain-specific characterization
Monoclonal antibody (mAb) products are extraordinarily heterogeneous due to the presence of a variety of enzymatic and chemical modifications, such as deamidation, isomerization, oxidation, glycosylation, glycation, and terminal cyclization. The modifications in different domains of the antibody mol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4171023/ https://ncbi.nlm.nih.gov/pubmed/24927271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28762 |
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