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Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor
Molecular details of epidermal growth factor receptor (EGFR) targeting by nimotuzumab, a therapeutic anti-cancer antibody, have been largely unknown. The current study delineated a functional map of their interface, based on phage display and extensive mutagenesis of both the target antigen and the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4171005/ https://ncbi.nlm.nih.gov/pubmed/24759767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28915 |
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