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Targeted genomic rearrangements using CRISPR/Cas technology
Genomic rearrangements are frequently observed in cancer cells but have been difficult to generate in a highly specific manner for functional analysis. Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver ev...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170920/ https://ncbi.nlm.nih.gov/pubmed/24759083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4728 |
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