Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, which occur in a progressive and irreversible manner. Superoxide dismutase (SOD) serves as a major antioxidant and neutralizes superoxide radicals throughout the body. In vivo studies have demonstrated...

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Bibliographic Details
Main Authors: Watanabe, Kenji, Shibuya, Shuichi, Ozawa, Yusuke, Nojiri, Hidetoshi, Izuo, Naotaka, Yokote, Koutaro, Shimizu, Takahiko
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2014
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170698/
https://ncbi.nlm.nih.gov/pubmed/25276767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/140165
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