Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Proteasomes are attractive emerging targets for anti-cancer therapies. Auranofin (Aur), a gold-containing compound clinically used to treat rheumatic arthritis, was recently approved by US Food and Drug Administration for Phase II clinical trial to treat cancer but its anti-cancer mechanism is poorl...

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Autori principali: Liu, Ningning, Li, Xiaofen, Huang, Hongbiao, Zhao, Chong, Liao, Siyan, Yang, Changshan, Liu, Shouting, Song, Wenbin, Lu, Xiaoyu, Lan, Xiaoying, Chen, Xin, Yi, Songgang, Xu, Li, Jiang, Lili, Zhao, Canguo, Dong, Xiaoxian, Zhou, Ping, Li, Shujue, Wang, Shunqing, Shi, Xianping, Dou, Ping Q., Wang, Xuejun, Liu, Jinbao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170648/
https://ncbi.nlm.nih.gov/pubmed/24977961
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