The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism

OBJECTIVES: The aim of this study was to evaluate the efficiency of cetuximab-based anti-EGFR treatment and Aurora kinase A / B knockdown as a function of Aurora kinase polymorphism in HNSCC cell lines. MATERIALS AND METHODS: First, protein expression of Aurora kinase A / B and EGFR and Aurora kinas...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Pickhard, Anja, Siegl, Michael, Baumann, Alexander, Huhn, Maximilian, Wirth, Markus, Reiter, Rudolf, Rudelius, Martina, Piontek, Guido, Brockhoff, Gero
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170642/
https://ncbi.nlm.nih.gov/pubmed/24980817
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