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Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from M. tuberculosis
Class II fructose 1,6-bisphosphate aldolases (FBA; E.C. 4.1.2.13) comprise one of two families of aldolases. Instead of forming a Schiff-base intermediate using an ε-amino group of a lysine side chain, class II FBAs utilize Zn(II) to stabilize a proposed hydroxyenolate intermediate (HEI) in the reve...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170518/ https://ncbi.nlm.nih.gov/pubmed/23298222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300928u |
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