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The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumors
The destruction of proteins via the ubiquitin-proteasome system is a multi-step, complex process involving polyubiquitination of substrate proteins, followed by proteolytic degradation by the macromolecular 26S proteasome complex. Inhibitors of the proteasome promote the accumulation of proteins tha...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170053/ https://ncbi.nlm.nih.gov/pubmed/24659480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-14-0005 |
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