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The E3 ubiquitin ligase TRIM33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation
NLRP3 is a key component of caspase-activating macromolecular protein complexes called inflammasomes. It has been found that DHX33 is a cytosolic double-stranded RNA (dsRNA) sensor for the NLRP3 inflammasome, which induces caspase-1-dependent production of IL-1β and IL18 upon activation. However, ho...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170004/ https://ncbi.nlm.nih.gov/pubmed/25172487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401448 |
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