Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals

Efficacy trials of adenovirus 5-vectored candidate HIV vaccines [recombinant Ad5 (rAd5)-HIV] were halted for futility due to lack of vaccine efficacy and unexpected excess HIV infections in the vaccine recipients. The potential immunologic basis for these observations is unclear. We comparatively ev...

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Detalhes bibliográficos
Main Authors: Hu, Haitao, Eller, Michael A., Zafar, Shah, Zhou, Yu, Gu, Mengnan, Wei, Zhi, Currier, Jeffrey R., Marovich, Mary A., Kibuuka, Hannah N., Bailer, Robert T., Koup, Richard A., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Ratto-Kim, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169982/
https://ncbi.nlm.nih.gov/pubmed/25197078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400446111
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