Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

In preclinical studies, endothelin receptor A (ET(A)) antagonists (ET(A)i) attenuated the progression of heart failure (HF). However, clinical HF trials failed to demonstrate beneficial effects of ET(A)i. These conflicting data may be explained by the possibility that established HF drugs such as ad...

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Detalhes bibliográficos
Main Authors: Lehmann, Lorenz H., Rostosky, Julia S., Buss, Sebastian J., Kreusser, Michael M., Krebs, Jutta, Mier, Walter, Enseleit, Frank, Spiger, Katharina, Hardt, Stefan E., Wieland, Thomas, Haass, Markus, Lüscher, Thomas F., Schneider, Michael D., Parlato, Rosanna, Gröne, Hermann-Josef, Haberkorn, Uwe, Yanagisawa, Masashi, Katus, Hugo A., Backs, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169911/
https://ncbi.nlm.nih.gov/pubmed/25197047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409026111
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