Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

In preclinical studies, endothelin receptor A (ET(A)) antagonists (ET(A)i) attenuated the progression of heart failure (HF). However, clinical HF trials failed to demonstrate beneficial effects of ET(A)i. These conflicting data may be explained by the possibility that established HF drugs such as ad...

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Main Authors: Lehmann, Lorenz H., Rostosky, Julia S., Buss, Sebastian J., Kreusser, Michael M., Krebs, Jutta, Mier, Walter, Enseleit, Frank, Spiger, Katharina, Hardt, Stefan E., Wieland, Thomas, Haass, Markus, Lüscher, Thomas F., Schneider, Michael D., Parlato, Rosanna, Gröne, Hermann-Josef, Haberkorn, Uwe, Yanagisawa, Masashi, Katus, Hugo A., Backs, Johannes
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169911/
https://ncbi.nlm.nih.gov/pubmed/25197047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409026111
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