Monovalent IgG4 molecules: Immunoglobulin Fc mutations that result in a monomeric structure

Antibodies have become the fastest growing class of biological therapeutics, in part due to their exquisite specificity and ability to modulate protein-protein interactions with a high biological potency. The relatively large size and bivalency of antibodies, however, limits their use as therapeutic...

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Bibliografiske detaljer
Main Authors: Wilkinson, Ian C., Fowler, Susan B., Machiesky, LeeAnn, Miller, Kenneth, Hayes, David B., Adib, Morshed, Her, Cheng, Borrok, M. Jack, Tsui, Ping, Burrell, Matthew, Corkill, Dominic J., Witt, Susanne, Lowe, David C., Webster, Carl I.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169034/
https://ncbi.nlm.nih.gov/pubmed/23567207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23941
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