Monovalent IgG4 molecules: Immunoglobulin Fc mutations that result in a monomeric structure

Antibodies have become the fastest growing class of biological therapeutics, in part due to their exquisite specificity and ability to modulate protein-protein interactions with a high biological potency. The relatively large size and bivalency of antibodies, however, limits their use as therapeutic...

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Autori principali: Wilkinson, Ian C., Fowler, Susan B., Machiesky, LeeAnn, Miller, Kenneth, Hayes, David B., Adib, Morshed, Her, Cheng, Borrok, M. Jack, Tsui, Ping, Burrell, Matthew, Corkill, Dominic J., Witt, Susanne, Lowe, David C., Webster, Carl I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169034/
https://ncbi.nlm.nih.gov/pubmed/23567207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23941
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