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Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype

Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is supposed to be involved in extracellular matrix stability and thus may play a key role in the inhibition of tumor progression. The current study is the first to analyze in depth ITIH5 expression as well as its potential clinical and functional impac...

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Autors principals: Kloten, Vera, Rose, Michael, Kaspar, Sophie, von Stillfried, Saskia, Knüchel, Ruth, Dahl, Edgar
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169021/
https://ncbi.nlm.nih.gov/pubmed/25093535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.32089
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