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Missing heritability of common diseases and treatments outside the protein-coding exome

Genetic factors strongly influence risk of common human diseases and treatment outcomes but the causative variants remain largely unknown; this gap has been called the ‘missing heritability’. We propose several hypotheses that in combination have the potential to narrow the gap. First, given a multi...

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Detalhes bibliográficos
Main Authors: Sadee, Wolfgang, Hartmann, Katherine, Seweryn, Michał, Pietrzak, Maciej, Handelman, Samuel K., Rempala, Grzegorz A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169001/
https://ncbi.nlm.nih.gov/pubmed/25107510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-014-1476-7
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