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Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS

Hundreds of genetic markers have shown associations with various complex diseases, yet the “missing heritability” remains alarmingly elusive. Combinatorial interactions may account for a substantial portion of this missing heritability, but their discoveries have been impeded by computational comple...

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Detalhes bibliográficos
Main Authors: Climer, Sharlee, Templeton, Alan R., Zhang, Weixiong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168982/
https://ncbi.nlm.nih.gov/pubmed/25233071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003766
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