Structure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of Mycobacteria

[Image: see text] 4′-Phosphopantetheinyl transferases (PPTase) post-translationally modify carrier proteins with a phosphopantetheine moiety, an essential reaction in all three domains of life. In the bacterial genus Mycobacteria, the Sfp-type PPTase activates pathways necessary for the biosynthesis...

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Bibliografiske detaljer
Main Authors: Vickery, Christopher R., Kosa, Nicolas M., Casavant, Ellen P., Duan, Shiteng, Noel, Joseph P., Burkart, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168790/
https://ncbi.nlm.nih.gov/pubmed/24963544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500263p
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