Transformation of Human Cathelicidin LL-37 into Selective, Stable, and Potent Antimicrobial Compounds

[Image: see text] This Letter reports a family of novel antimicrobial compounds obtained by combining peptide library screening with structure-based design. Library screening led to the identification of a human LL-37 peptide resistant to chymotrypsin. This d-amino-acid-containing peptide template w...

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Bibliographic Details
Main Authors: Wang, Guangshun, Hanke, Mark L., Mishra, Biswajit, Lushnikova, Tamara, Heim, Cortney E., Chittezham Thomas, Vinai, Bayles, Kenneth W., Kielian, Tammy
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168778/
https://ncbi.nlm.nih.gov/pubmed/25061850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500475y
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