Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance

AIMS: A large interindividual variability in plasma concentrations has been reported in patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition in a patient population recruited from a natu...

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Dades bibliogràfiques
Autors principals: Noetzli, Muriel, Guidi, Monia, Ebbing, Karsten, Eyer, Stephan, Wilhelm, Laurence, Michon, Agnès, Thomazic, Valérie, Stancu, Ioana, Alnawaqil, Abdel-Messieh, Bula, Christophe, Zumbach, Serge, Gaillard, Michel, Giannakopoulos, Panteleimon, von Gunten, Armin, Csajka, Chantal, Eap, Chin B
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2014
Matèries:
Pharmacogenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168388/
https://ncbi.nlm.nih.gov/pubmed/24433464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12325
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