Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance

AIMS: A large interindividual variability in plasma concentrations has been reported in patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition in a patient population recruited from a natu...

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Detalhes bibliográficos
Main Authors: Noetzli, Muriel, Guidi, Monia, Ebbing, Karsten, Eyer, Stephan, Wilhelm, Laurence, Michon, Agnès, Thomazic, Valérie, Stancu, Ioana, Alnawaqil, Abdel-Messieh, Bula, Christophe, Zumbach, Serge, Gaillard, Michel, Giannakopoulos, Panteleimon, von Gunten, Armin, Csajka, Chantal, Eap, Chin B
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168388/
https://ncbi.nlm.nih.gov/pubmed/24433464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12325
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