Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation

We have previously reported on a unique patient in whom homozygosity for a mutation at IRF8 (IRF8(K108E)) causes a severe immunodeficiency. Laboratory evaluation revealed a highly unusual myeloid compartment, remarkable for the complete absence of CD14(+) and CD16(+) monocytes, absence of CD11c(+) c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Salem, Sandra, Langlais, David, Lefebvre, François, Bourque, Guillaume, Bigley, Venetia, Haniffa, Muzz, Casanova, Jean-Laurent, Burk, David, Berghuis, Albert, Butler, Karina M., Leahy, Timothy Ronan, Hambleton, Sophie, Gros, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168344/
https://ncbi.nlm.nih.gov/pubmed/25122610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-570879
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados