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Multiple domains of tetanus toxin direct entry into primary neurons
Tetanus toxin elicits spastic paralysis by cleaving VAMP-2 to inhibit neurotransmitter release in inhibitory neurons of the central nervous system. While the retrograde transport of TeNT from endosomes has been described, the initial steps that define how TeNT initiates trafficking to the retrograde...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4167930/ https://ncbi.nlm.nih.gov/pubmed/25040808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12197 |
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