Folic acid pathway single nucleotide polymorphisms associated with methotrexate significant adverse events in United States veterans with rheumatoid arthritis

OBJECTIVE: Methotrexate (MTX) is the cornerstone medication in the treatment of rheumatoid arthritis (RA). We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrah...

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Main Authors: Davis, Lisa A., Polk, Brooke, Mann, Alyse, Wolff, Roger K., Kerr, Gail S., Reimold, Andreas M., Cannon, Grant W., Mikuls, Ted R., Caplan, Liron
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167828/
https://ncbi.nlm.nih.gov/pubmed/24447348
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