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Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of α4βδ GABA(A) receptors

Hippocampal α4βδ GABA(A) receptors (GABA(A)-R) are increased following progesterone withdrawal (PWD) in a rodent model of premenstrual anxiety. This α4βδ receptor isoform uniquely responds to the GABA agonist gaboxadol (THIP) with a maximum current greater than that gated by GABA, and is potentiated...

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Detalhes bibliográficos
Main Authors: Gulinello, M., Gong, Q. H., Smith, S. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167748/
https://ncbi.nlm.nih.gov/pubmed/12544828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.wnr.0000050303.92401.9e
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