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The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing

piRNAs guide an adaptive genome defense system that silences transposons during germline development. The Drosophila HP1 homolog Rhino is required for germline piRNA production. We show that Rhino binds specifically to the heterochromatic clusters that produce piRNA precursors, and that binding dire...

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Autors principals: Zhang, Zhao, Wang, Jie, Schultz, Nadine, Zhang, Fan, Parhad, Swapnil S., Tu, Shikui, Vreven, Thom, Zamore, Phillip D., Weng, Zhiping, Theurkauf, William E.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167631/
https://ncbi.nlm.nih.gov/pubmed/24906152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.04.030
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