Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development

HuR is a ubiquitous nucleocytoplasmic RNA binding protein that exerts pleiotropic effects on cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression...

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Hoofdauteurs: Giammanco, Antonina, Blanc, Valerie, Montenegro, Grace, Klos, Coen, Xie, Yan, Kennedy, Susan, Luo, Jianyang, Chang, Sung-Hee, Hla, Timothy, Nalbantoglu, ILKe, Dharmarajan, Sekhar, Davidson, Nicholas O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167566/
https://ncbi.nlm.nih.gov/pubmed/25085247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0726
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