Greater frequency of CD5-negative CD8(+) T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation

BACKGROUND: The CD5 protein antagonizes phosphorylation events downstream of T cell receptor (TCR) engagement to decrease T cell responsiveness. CD5-negative T cell clones respond preferentially over their CD5(+) counterparts against cells with low human histocompatibility-linked leukocyte antigen (...

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Hlavní autoři: Penney, Stephen J, Gallant, Maureen E, Grant, Michael D
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167305/
https://ncbi.nlm.nih.gov/pubmed/25237383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-11-30
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