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Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus

Valnoctamide (VCD), a derivative of valproate, suppresses electrographic seizures in animal models of status epilepticus (SE), even when the seizures are resistant to benzodiazepines (BZDs). We therefore tested the effect of VCD on miniature inhibitory post-synaptic currents (mIPSCs) in CA1 pyramida...

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Bibliographic Details
Main Authors: Spampanato, Jay, Dudek, F. Edward
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167227/
https://ncbi.nlm.nih.gov/pubmed/24995528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12702
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