Systemic DNA Damage Accumulation Under in Vivo Tumor Growth can be Inhibited by the Antioxidant Tempol

AIMS: Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both adjacent to and distant from the tumor site...

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Main Authors: Georgakilas, Alexandros G., Redon, Christophe E., Ferguson, Nicholas F., Kryston, Thomas B., Parekh, Palak, Dickey, Jennifer S., Nakamura, Asako J., Mitchell, James B., Bonner, William M., Martin, Olga A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167057/
https://ncbi.nlm.nih.gov/pubmed/25069035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.07.030
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